FOLFIRI Combined with Bevacizumab as First-Line Treatment for Metastatic Colorectal Cancer Patients with Hyperbilirubinemia after UGT1A1 Genotyping

نویسندگان

  • Yung-Sung Yeh
  • Meng-Lin Huang
  • Se-Fen Chang
  • Chin-Fan Chen
  • Huang-Ming Hu
  • Jaw-Yuan Wang
چکیده

OBJECTIVE To report a metastatic colorectal cancer patient with hyperbilirubinemia treated with a combination of bevacizumab and FOLFIRI (5-fluorouracil, leucovorin, and irinotecan) using uridine diphosphate glucuronosyl transferase (UGT1A1) genotyping. CLINICAL PRESENTATION AND INTERVENTION A 46-year-old male was diagnosed with rectosigmoid colon cancer with liver metastases and hyperbilirubinemia presenting with severe jaundice. UGT1A1 genotyping was used before therapy to ascertain whether genotype-adjusted dosages of irinotecan plus bevacizumab could alleviate the toxicity. Then, the patient was treated with FOLFIRI. CONCLUSION The FOLFIRI regimen was successfully used in this patient without concerns regarding toxicity.

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عنوان ژورنال:

دوره 23  شماره 

صفحات  -

تاریخ انتشار 2014